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  • 2020 New Style Triamterene And Hydrochlorothiazide - LOXO-101 1223403-58-4  – CPF

    2020 New Style Triamterene And Hydrochlorothiazide - LOXO-101 1223403-58-4 – CPF

    Background IC50: low nanomolar range for inhibition of all TRK family members LOXO-101 is a tropomyosin receptor kinases (TRK) inhibitor. The TRK family of neurotrophin receptors and their neurotrophin ligands regulate neuron growth, differentiation and survival. In vitro: In previous study, LOXO-101 was evaluated for off-target kinase enzyme inhibition against a panel of non-TRK kinases at a concentration of 1,000 nM and ATP concentrations around the Km. Results showed that LOXO-101 had grea...
  • Hot New Products Thalidomide Uses - Agomelatine  – CPF

    Hot New Products Thalidomide Uses - Agomelatine – CPF

    Background Agomelatine is an agonist of melatonin receptors and an antagonist of the serotonin 5-HT2C receptor with Ki values of 0.062nM and 0.268nM and IC50 value of 0.27μM, respectively for MT1, MT2 and 5-HT2C [1]. Agomelatine is a unique antidepressant and is developed for treatment of major depressive disorder (MDD). Agomelatine is selective against 5-HT2C. It shows low affinities to cloned human 5-HT2A and 5-HT1A. For melatonin receptors, agomelatine shows similar affinities to cloned hu...
  • Factory For Baloxavir Marboxil People Also Search For - Chlorothiazide  – CPF

    Factory For Baloxavir Marboxil People Also Search For - Chlorothiazide – CPF

    Background Chlorothiazide is an inhibitor of carbonic anhydrase and is slightly less potent than acetazolamide. This compound has been shown to block reabsorption of sodium and chloride ions. Description Chlorothiazide is a diuretic and antihypertensive. (IC50=3.8 mM) Target: Others Chlorothiazide sodium (Diuril) is a diuretic used within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. It is also used as an antihypertensive. Most often...
  • Popular Design for Doxycycline Hcl 100mg - Dabigatran Etexilate Mesylate  – CPF

    Popular Design for Doxycycline Hcl 100mg - Dabigatran Etexilate Mesylate – CPF

    Description Dabigatran etexilate mesylate (BIBR 1048MS) is an orally active prodrug of Dabigatran. Dabigatran etexilate mesylate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation. Background Description: IC50 Value: 4.5nM (Ki); 10nM(Thrombin-induced platelet aggregation) [1] Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) undergoing advanced clinical development as its orally active prodrug,dabiga...
  • Factory best selling Doxycycline Hyclate Before And After - Doxycycline Monohydrate  – CPF

    Factory best selling Doxycycline Hyclate Before And After - Doxycycline Monohydrate – CPF

    多西环素一水物 Doxycycline Monohydrate 17086-28-1 USP/EP Generic Name: doxycycline (DOX i SYE kleen) Brand Names: Acticlate, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Monodox, Morgidox, Oracea, Oraxyl, Periostat Targadox, Vibramycin calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs Dosage Form: capsule Doxycycline is a tetracycline antibiotic that fights bacteria in the body and  an antibiotic and broad-spectrum metalloproteinase (MMP) inhibi...
  • OEM Supply Is Hydrochlorothiazide - Rosuvastatin Calcium  – CPF

    OEM Supply Is Hydrochlorothiazide - Rosuvastatin Calcium – CPF

    瑞舒伐他汀钙 Rosuvastatin Calcium 147098-20-2 In-House/CEP     RSM(Crystal) 147118-40-9 In-House     RSM(Crude) 147118-40-9 In-House     RSP — In-House     RS-8 147118-36-3 In-House     RS-8-1 147118-37-4 In-House     TP-8 131466-61-0 In-House     TP-11 147118-35-2 In-House     TP-13 147118-39-6 In-House     RS-10 289042-12-2 In-House     RS-11 355806-00-7 In-House Description Rosuvastatin Calcium (BANM, JAN, USAN) is known as Rosuvastatin in the US. a...
  • factory customized Doxycycline Monohydrate 100mg For Chlamydia - Lenalidomide  – CPF

    factory customized Doxycycline Monohydrate 100mg For Chlamydia - Lenalidomide – CPF

    Description Lenalidomide (CC-5013) is a derivative of Thalidomide and an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells. Background Lenalidomide ...
  • Best Price on Doxycycline Mono 100 - LOXO-101 1223403-58-4  – CPF

    Best Price on Doxycycline Mono 100 - LOXO-101 1223403-58-4 – CPF

    Background IC50: low nanomolar range for inhibition of all TRK family members LOXO-101 is a tropomyosin receptor kinases (TRK) inhibitor. The TRK family of neurotrophin receptors and their neurotrophin ligands regulate neuron growth, differentiation and survival. In vitro: In previous study, LOXO-101 was evaluated for off-target kinase enzyme inhibition against a panel of non-TRK kinases at a concentration of 1,000 nM and ATP concentrations around the Km. Results showed that LOXO-101 had grea...
  • Top Quality Rivaroxaban Supplier - Niraparib 1038915-60-4  – CPF

    Top Quality Rivaroxaban Supplier - Niraparib 1038915-60-4 – CPF

    Description Niraparib (MK-4827) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity.   In Vitro Niraparib (MK-4827) inhibits PARP activity with EC50=4 nM and EC90=45 nM in a whole cell assay. MK-4827 inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10-100 nM range. MK-4827 displays exce...
  • China Wholesale Tractor Mounted Log Splitter Factory - Niraparib 1038915-60-4  – CPF

    China Wholesale Tractor Mounted Log Splitter Factory - Niraparib 1038915-60-4 – CPF

    Description Niraparib (MK-4827) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity.   In Vitro Niraparib (MK-4827) inhibits PARP activity with EC50=4 nM and EC90=45 nM in a whole cell assay. MK-4827 inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10-100 nM range. MK-4827 displays exce...
  • China Wholesale Ticagrelor Bnf Quotes - Apixaban  – CPF

    China Wholesale Ticagrelor Bnf Quotes - Apixaban – CPF

    Background Apixaban is a highly selective and reversible inhibitor of Factor Xa with Ki values of 0.08 nM and 0.17 nM in human and rabbit, respectively[1]. Factor X, also known by the eponym Stuart–Prower factor, is an enzyme of the coagulation cascade. Factor X is activated, by hydrolysis, into factor Xa by both factor IX. Factor Xa is the activated form of the coagulation factorthrombokinase.Inhibiting Factor Xa could offer an alternate method for anticoagulation. Direct Xa inhibitors are p...
  • Hot sale Factory Folic Acid - Doxycycline Hyclate  – CPF

    Hot sale Factory Folic Acid - Doxycycline Hyclate – CPF

    Background Doxycycline hyclate is an antibiotic [1]. Doxycycline hyclate is a derivative of tetracycline and possesses the activities of anti-inflammatory and antimicrobial. Doxycycline inhibits dengue virus replication in vitro with a temperature-dependent manner. The IC50 value is 52.3μM at 37°C and 26.7μM at 40°C. It inhibits the dengue virus via inhibiting the NS2B-NS3 serine protease of the virus. 60μM doxycycline reduces the CPE of the DNEV2-infected cells [1]. Doxycycline is found to b...