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  • Hot-selling Favipiravir Manufacturer - Tofacitnib Citrate  – CPF

    Hot-selling Favipiravir Manufacturer - Tofacitnib Citrate – CPF

    Background Tofacitinib citrate, also known as CP-690550 citrate, is a potent inhibitor of janus kinase 3 (JAK3), a hematopoetic cell-restricted tyrosine kinase involved in signal transduction regulating lymphocyte survival, proliferation, differentiation, and apoptosis.  The inhibition is JAK3 specific with a selectivity 1000-fold more than other non-JAK family kinases. Besides inhibiting JAKS (IC50 = 1 nM), tofacitinib citrate also inhibits janus kinase 2 (JAK2) and janus kinase 1 (JAK1) wit...
  • China Cheap price Rosuvastatin Supplier - Chlorothiazide  – CPF

    China Cheap price Rosuvastatin Supplier - Chlorothiazide – CPF

    Background Chlorothiazide is an inhibitor of carbonic anhydrase and is slightly less potent than acetazolamide. This compound has been shown to block reabsorption of sodium and chloride ions. Description Chlorothiazide is a diuretic and antihypertensive. (IC50=3.8 mM) Target: Others Chlorothiazide sodium (Diuril) is a diuretic used within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. It is also used as an antihypertensive. Most often...
  • 2020 Good Quality Palbociclib Ribociclib - Canagliflozin  – CPF

    2020 Good Quality Palbociclib Ribociclib - Canagliflozin – CPF

    Background Canagliflozin is a novel, potent, and highly selective sodium glucose co-transporter (SGLT) 2 inhibitor [1]. It has been proved that Canagliflozin can increase urine glucose excretion by reducing the renal glucose threshold and by decreasing the filtered glucose re-absorption [2]. Canagliflozin has been shown to inhibit the Na+-mediated 14C-AMG intakes in CHO-hSGLT2, CHO-rat SGLT2 and CHO-mouse SGLT2 with IC50 values of 4.4, 3.7 and 2.0 nM, respectively [1]. Canagliflozin has been ...
  • China Wholesale Ticagrelor Suppliers - Captopril  – CPF

    China Wholesale Ticagrelor Suppliers - Captopril – CPF

    Description Captopril (SQ-14534) is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE). In Vitro Captopril (SQ-14534) has been shown to have similar morbidity and mortality benefits to those of diuretics and beta-blockers in hypertensive patients. Captopril (SQ-14534) has been shown to delay the progression of diabetic nephropathy, and enalapril and lisinopril prevent the development of nephropathy in normoalbuminuric patients with diabetes[1]. An equimolar ratio of the c...
  • China Wholesale Heavy Duty Log Splitter Suppliers - Captopril  – CPF

    China Wholesale Heavy Duty Log Splitter Suppliers - Captopril – CPF

    Description Captopril (SQ-14534) is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE). In Vitro Captopril (SQ-14534) has been shown to have similar morbidity and mortality benefits to those of diuretics and beta-blockers in hypertensive patients. Captopril (SQ-14534) has been shown to delay the progression of diabetic nephropathy, and enalapril and lisinopril prevent the development of nephropathy in normoalbuminuric patients with diabetes[1]. An equimolar ratio of the c...
  • Big Discount Obeticholic Acid Manufacturer - Rivaroxaban  – CPF

    Big Discount Obeticholic Acid Manufacturer - Rivaroxaban – CPF

    Background Rivaroxaban, 5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide, is a potent small-molecule inhibitor of factor Xa which is a coagulation factor at a critical juncture in the blood coagulation pathway resulting in the generation of thrombin and the formation of clot. Rivaroxaban binds to the Tyr288 in S1 pocket of factor Xa through the interaction of Tyr288 and the chlorine substituent of the chlorothiophene moiety. The inhi...
  • China Wholesale Fenofibrate Rosuvastatin Calcium Quotes - Pregabalin  – CPF

    China Wholesale Fenofibrate Rosuvastatin Calcium Quotes - Pregabalin – CPF

    Pregabalin is not a GABAA or GABAB receptor agonist. Pregabalin is a gabapentinoid and acts by inhibiting certain calcium channels. Specifically it is a ligand of the auxiliary α2δ subunit site of certain voltage-dependent calcium channels (VDCCs), and thereby acts as an inhibitor of α2δ subunit-containing VDCCs. There are two drug-binding α2δ subunits, α2δ-1 and α2δ-2, and pregabalin shows similar affinity for (and hence lack of selectivity between) these two sites. Pregabalin is selective i...
  • OEM/ODM Supplier Pregabalina Lyrica - Baloxavir Marboxil 1985606-14-1  – CPF

    OEM/ODM Supplier Pregabalina Lyrica - Baloxavir Marboxil 1985606-14-1 – CPF

    Background Baloxavir marboxil is an antiviral drug and is an endonuclease inhibitor. In rats and monkeys, the blood concentration of the drug is lower than the minimum detection amount in a single oral administration of the drug. In preclinical influenza A and B infection models (including strains that are resistant to existing antiviral drugs), Baloxavir marboxil has a certain effect. Chemical Properties Storage Store at -20°C M.Wt 571.55 Cas No. 1985606-14-1 Formula C27H23F2N3O7S ...
  • Good User Reputation for Doxycycline Monohydrate For Rosacea - Enalapril Maleate  – CPF

    Good User Reputation for Doxycycline Monohydrate For Rosacea - Enalapril Maleate – CPF

    Background Enalapril Maleate Description Enalapril (maleate) (MK-421 (maleate)), the active metabolite of enalapril, is an angiotensin-converting enzyme (ACE) inhibitor. In Vivo Enalapril (MK-421) is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to enalaprilat following oral administration. Enalapril (MK-421) is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angio...
  • Wholesale Discount Rosuvastatin Calcium 5 Mg - Dabigatran Etexilate Mesylate  – CPF

    Wholesale Discount Rosuvastatin Calcium 5 Mg - Dabigatran Etexilate Mesylate – CPF

    Description Dabigatran etexilate mesylate (BIBR 1048MS) is an orally active prodrug of Dabigatran. Dabigatran etexilate mesylate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation. Background Description: IC50 Value: 4.5nM (Ki); 10nM(Thrombin-induced platelet aggregation) [1] Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) undergoing advanced clinical development as its orally active prodrug,dabiga...
  • OEM Manufacturer Daclatasvir Tablets 60 Mg - Baloxavir Marboxil 1985606-14-1  – CPF

    OEM Manufacturer Daclatasvir Tablets 60 Mg - Baloxavir Marboxil 1985606-14-1 – CPF

    Background Baloxavir marboxil is an antiviral drug and is an endonuclease inhibitor. In rats and monkeys, the blood concentration of the drug is lower than the minimum detection amount in a single oral administration of the drug. In preclinical influenza A and B infection models (including strains that are resistant to existing antiviral drugs), Baloxavir marboxil has a certain effect. Chemical Properties Storage Store at -20°C M.Wt 571.55 Cas No. 1985606-14-1 Formula C27H23F2N3O7S ...
  • Low MOQ for Doxycycline Hyclate Capsules - Ticagrelor  – CPF

    Low MOQ for Doxycycline Hyclate Capsules - Ticagrelor – CPF

    Background Ticagrelor is a novel antagonist of the P2Y12 receptor [1]. Ticagrelor has been reported to inhibit the prothrombotic effects of ADP on the platelet by against the P2Y12 receptor. Ticagrelor has shown the complete inhibition of platelet aggregation ex vivo. In addition Ticagrelor has suggested a dose-dependent inhibition of platelet aggregation in human being. Apart from these, Ticagrelor has also demonstrated an orally, actively, reversibly binding antagonist. Unlike other inhibit...