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China Wholesale Rosuvastatin Calcium Use Suppliers - Niraparib 1038915-60-4 – CPF
Description Niraparib (MK-4827) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity. In Vitro Niraparib (MK-4827) inhibits PARP activity with EC50=4 nM and EC90=45 nM in a whole cell assay. MK-4827 inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10-100 nM range. MK-4827 displays exce... -
Manufactur standard Apixaban Supplier - Daclatasvir Dihydrochloride – CPF
Description Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir dihydrochloride is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 µM and 3.27 µM, respectively. IC50 & Target EC50: 50 pM (HCV replicon genotype 1a), 9 pM (HCV replicon genotype 1b), 71 pM (HCV replicon genotype 2a), 146 pM (HCV replicon ... -
Best quality Triamterene Hydrochlorothiazide - Velpatasvir(PVP) – CPF
Foreign Names Velpatasvirum (Latin) Velpatasvir (German) Velpatasvir (French) Velpatasvir (Spanish) Generic Names Velpatasvir (OS: USAN) GS-5816 (IS) UNII-KCU0C7RS7Z (IS) Multi-ingredient medications containing velpatasvir:sofosbuvir/velpatasvir systemic Brand names: Epclusa Drug class(es): antiviral combinations Sofosbuvir/velpatasvir systemic is used in the treatment of:Hepatitis C sofosbuvir/velpatasvir/voxilaprevir systemic Brand names: Vosevi Drug class(es): antiviral combinations Sofosb... -
OEM/ODM China Doxycycline Hyclate 500mg - Baloxavir Marboxil 1985606-14-1 – CPF
Background Baloxavir marboxil is an antiviral drug and is an endonuclease inhibitor. In rats and monkeys, the blood concentration of the drug is lower than the minimum detection amount in a single oral administration of the drug. In preclinical influenza A and B infection models (including strains that are resistant to existing antiviral drugs), Baloxavir marboxil has a certain effect. Chemical Properties Storage Store at -20°C M.Wt 571.55 Cas No. 1985606-14-1 Formula C27H23F2N3O7S ... -
Special Price for Daclatasvir Plus Sofosbuvir - Chlorothiazide – CPF
Background Chlorothiazide is an inhibitor of carbonic anhydrase and is slightly less potent than acetazolamide. This compound has been shown to block reabsorption of sodium and chloride ions. Description Chlorothiazide is a diuretic and antihypertensive. (IC50=3.8 mM) Target: Others Chlorothiazide sodium (Diuril) is a diuretic used within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. It is also used as an antihypertensive. Most often... -
Original Factory Pregabalin 300 - Pitavastatin Calcium – CPF
匹伐他汀钙 Pitavastatin 147526-32-7 In-House PI-5 3800-06-4 In-House PI-6 145516-11-4 In-House PI-7 121660-11-5 In-House Description Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (L... -
China wholesale Hydrochlorothiazide Manufacturer - Daclatasvir Dihydrochloride – CPF
Description Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir dihydrochloride is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 µM and 3.27 µM, respectively. IC50 & Target EC50: 50 pM (HCV replicon genotype 1a), 9 pM (HCV replicon genotype 1b), 71 pM (HCV replicon genotype 2a), 146 pM (HCV replicon ... -
factory customized Doxycycline Monohydrate 100mg For Chlamydia - Atorvastatin Calcium – CPF
Background Atorvastatin Calcium is a potent inhibitor of HMG-CoA reductase with IC50 value of 150 nM[1]. HMG-CoA reductase is the key enzyme of the mevalonate pathway which produces cholesterol. HMG-CoA is the rate-limiting enzyme and is important for lowering the blood cholesterol levels. HMG-CoA reductase is located in the endoplasmic reticulum and contains eight transmembrane domains. The inhibitors of HMG-CoA reductase can induce the LDL (low density lipoprotein) receptors expression in t... -
Factory wholesale Doxycycline Hyclate For Chlamydia - Sugammadex Sodium – CPF
舒更葡糖钠 Sugammadex Sodium 343306-79-6 In-House Description Sugammadex sodium is a synthetic γ-cyclodextrin derivative, and acts as a new reversal agent for neuromuscular block. Generic Name: sugammadex (soo GAM ma dex) Brand Name: Bridion Sugammadex reverses the effects of certain medications that are given during surgical procedures to relax your muscles. Sugammadex is used at the end of surgery, to help restore muscle function that has been blocked during surgery by the other ... -
professional factory for Tofacitinib Supplier - Bictegravir 1611493-60-7 – CPF
Description Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM. In Vitro Bictegravir (BIC) inhibits the strand transfer activity with an IC50 of 7.5± 0.3 nM. Relative to its inhibition of strand transfer activity, Bictegravir is a much weaker inhibitor of 3′-processing activity of HIV-1 IN, with an IC50 of 241±51 nM. Bictegravir enhances the accumulation of 2-LTR circles ~5-fold relative to the mock-treated control and reduces the amount of authentic integrati... -
Wholesale Discount Rosuvastatin Calcium 5 Mg - Dabigatran Etexilate Mesylate – CPF
Description Dabigatran etexilate mesylate (BIBR 1048MS) is an orally active prodrug of Dabigatran. Dabigatran etexilate mesylate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation. Background Description: IC50 Value: 4.5nM (Ki); 10nM(Thrombin-induced platelet aggregation) [1] Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) undergoing advanced clinical development as its orally active prodrug,dabiga... -
Europe style for Baloxavir Marboxil Dosage - LOXO-101 1223403-58-4 – CPF
Background IC50: low nanomolar range for inhibition of all TRK family members LOXO-101 is a tropomyosin receptor kinases (TRK) inhibitor. The TRK family of neurotrophin receptors and their neurotrophin ligands regulate neuron growth, differentiation and survival. In vitro: In previous study, LOXO-101 was evaluated for off-target kinase enzyme inhibition against a panel of non-TRK kinases at a concentration of 1,000 nM and ATP concentrations around the Km. Results showed that LOXO-101 had grea...
