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  • China Wholesale Ticagrelor Classification Factory - Tofacitnib Citrate  – CPF

    China Wholesale Ticagrelor Classification Factory - Tofacitnib Citrate – CPF

    Background Tofacitinib citrate, also known as CP-690550 citrate, is a potent inhibitor of janus kinase 3 (JAK3), a hematopoetic cell-restricted tyrosine kinase involved in signal transduction regulating lymphocyte survival, proliferation, differentiation, and apoptosis.  The inhibition is JAK3 specific with a selectivity 1000-fold more than other non-JAK family kinases. Besides inhibiting JAKS (IC50 = 1 nM), tofacitinib citrate also inhibits janus kinase 2 (JAK2) and janus kinase 1 (JAK1) wit...
  • 18 Years Factory Canagliflozin Dosage - Pitavastatin Calcium  – CPF

    18 Years Factory Canagliflozin Dosage - Pitavastatin Calcium – CPF

    匹伐他汀钙 Pitavastatin 147526-32-7 In-House     PI-5 3800-06-4 In-House     PI-6 145516-11-4 In-House     PI-7 121660-11-5 In-House   Description Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (L...
  • Fast delivery Invokana Canagliflozin - Ticagrelor  – CPF

    Fast delivery Invokana Canagliflozin - Ticagrelor – CPF

    Background Ticagrelor is a novel antagonist of the P2Y12 receptor [1]. Ticagrelor has been reported to inhibit the prothrombotic effects of ADP on the platelet by against the P2Y12 receptor. Ticagrelor has shown the complete inhibition of platelet aggregation ex vivo. In addition Ticagrelor has suggested a dose-dependent inhibition of platelet aggregation in human being. Apart from these, Ticagrelor has also demonstrated an orally, actively, reversibly binding antagonist. Unlike other inhibit...
  • Big discounting Doxycycline Monohydrate 50 Mg Tablet - Pregabalin  – CPF

    Big discounting Doxycycline Monohydrate 50 Mg Tablet - Pregabalin – CPF

    Pregabalin is not a GABAA or GABAB receptor agonist. Pregabalin is a gabapentinoid and acts by inhibiting certain calcium channels. Specifically it is a ligand of the auxiliary α2δ subunit site of certain voltage-dependent calcium channels (VDCCs), and thereby acts as an inhibitor of α2δ subunit-containing VDCCs. There are two drug-binding α2δ subunits, α2δ-1 and α2δ-2, and pregabalin shows similar affinity for (and hence lack of selectivity between) these two sites. Pregabalin is selective i...
  • Trending Products Irbesartan And Hydrochlorothiazide Tablets - Niraparib 1038915-60-4  – CPF

    Trending Products Irbesartan And Hydrochlorothiazide Tablets - Niraparib 1038915-60-4 – CPF

    Description Niraparib (MK-4827) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity.   In Vitro Niraparib (MK-4827) inhibits PARP activity with EC50=4 nM and EC90=45 nM in a whole cell assay. MK-4827 inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10-100 nM range. MK-4827 displays exce...
  • 2020 Latest Design Apo Hydrochlorothiazide - Ledipasvir Actone /PVP  – CPF

    2020 Latest Design Apo Hydrochlorothiazide - Ledipasvir Actone /PVP – CPF

    雷迪帕韦丙酮/聚维酮 Ledipasvir actone/PVP 1256388-51-8 In-House     LPSM1   1256387-87-7 In-House     LPSM1-5   291775-59-2 In-House     LPSM2   1129634-44-1 In-House     LPS-6   1441670-89-8 In-House Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. In Vitro Ledipasvir acetone is considered the active ingredient, which ...
  • Good Wholesale Vendors Canagliflozin Hemihydrate - Rivaroxaban  – CPF

    Good Wholesale Vendors Canagliflozin Hemihydrate - Rivaroxaban – CPF

    Background Rivaroxaban, 5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide, is a potent small-molecule inhibitor of factor Xa which is a coagulation factor at a critical juncture in the blood coagulation pathway resulting in the generation of thrombin and the formation of clot. Rivaroxaban binds to the Tyr288 in S1 pocket of factor Xa through the interaction of Tyr288 and the chlorine substituent of the chlorothiophene moiety. The inhi...
  • New Arrival China Sofosbuvir Tablets 400 Mg - Doxycycline Hyclate  – CPF

    New Arrival China Sofosbuvir Tablets 400 Mg - Doxycycline Hyclate – CPF

    Background Doxycycline hyclate is an antibiotic [1]. Doxycycline hyclate is a derivative of tetracycline and possesses the activities of anti-inflammatory and antimicrobial. Doxycycline inhibits dengue virus replication in vitro with a temperature-dependent manner. The IC50 value is 52.3μM at 37°C and 26.7μM at 40°C. It inhibits the dengue virus via inhibiting the NS2B-NS3 serine protease of the virus. 60μM doxycycline reduces the CPE of the DNEV2-infected cells [1]. Doxycycline is found to b...
  • High reputation Doxycycline Monohydrate 100 Mg Oral Capsule - Captopril  – CPF

    High reputation Doxycycline Monohydrate 100 Mg Oral Capsule - Captopril – CPF

    Description Captopril (SQ-14534) is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE). In Vitro Captopril (SQ-14534) has been shown to have similar morbidity and mortality benefits to those of diuretics and beta-blockers in hypertensive patients. Captopril (SQ-14534) has been shown to delay the progression of diabetic nephropathy, and enalapril and lisinopril prevent the development of nephropathy in normoalbuminuric patients with diabetes[1]. An equimolar ratio of the c...
  • China Wholesale Rosuvastatin Calcium 20 Manufacturers - Bictegravir 1611493-60-7  – CPF

    China Wholesale Rosuvastatin Calcium 20 Manufacturers - Bictegravir 1611493-60-7 – CPF

    Description Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM. In Vitro Bictegravir (BIC) inhibits the strand transfer activity with an IC50 of 7.5± 0.3 nM. Relative to its inhibition of strand transfer activity, Bictegravir is a much weaker inhibitor of 3′-processing activity of HIV-1 IN, with an IC50 of 241±51 nM. Bictegravir enhances the accumulation of 2-LTR circles ~5-fold relative to the mock-treated control and reduces the amount of authentic integrati...
  • professional factory for Tofacitinib Supplier - Ticagrelor  – CPF

    professional factory for Tofacitinib Supplier - Ticagrelor – CPF

    Background Ticagrelor is a novel antagonist of the P2Y12 receptor [1]. Ticagrelor has been reported to inhibit the prothrombotic effects of ADP on the platelet by against the P2Y12 receptor. Ticagrelor has shown the complete inhibition of platelet aggregation ex vivo. In addition Ticagrelor has suggested a dose-dependent inhibition of platelet aggregation in human being. Apart from these, Ticagrelor has also demonstrated an orally, actively, reversibly binding antagonist. Unlike other inhibit...
  • Best Price for Pregabalin Methylcobalamin Uses - Chlorothiazide  – CPF

    Best Price for Pregabalin Methylcobalamin Uses - Chlorothiazide – CPF

    Background Chlorothiazide is an inhibitor of carbonic anhydrase and is slightly less potent than acetazolamide. This compound has been shown to block reabsorption of sodium and chloride ions. Description Chlorothiazide is a diuretic and antihypertensive. (IC50=3.8 mM) Target: Others Chlorothiazide sodium (Diuril) is a diuretic used within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. It is also used as an antihypertensive. Most often...