China China Wholesale Calcium Rosuvastatin Suppliers - Sacubitril Hemicalcium – CPF manufacturers and suppliers

China Wholesale Calcium Rosuvastatin Suppliers - Sacubitril Hemicalcium – CPF

Short Description:

Product Detail

Product Tags

Feedback (2)

Dedicated to strict high-quality management and considerate purchaser support, our experienced employees members are usually available to discuss your specifications and be certain full shopper satisfaction for Doxycycline Monohydrate 100mg Dosage, Tab Ticagrelor, Amlodipine Hydrochlorothiazide, The principle of our company is to provide high-quality products, professional service, and honest communication. Welcome all friends to place trial order for creating a long-term business relationship.

China Wholesale Calcium Rosuvastatin Suppliers - Sacubitril Hemicalcium – CPF Detail:

沙库比曲半钙盐	Sacubitril Hemicalcium	1369773-39-6	In-House
沙库比曲钠盐		149690-05-1	In-House
LCZ-4		1426129-50-1	In-House
LCZ-7		1012341-48-8	In-House
LCZ-8		1012341-50-2	In-House
LCZ-9		149690-12-0	In-House

Background

AHU-377 hemicalcium salt is a hemicalcium salt form of AHU-377. It is an inhibitor of neprilysin with IC50 value of 5 nM [1].

AHU-377 and the angiotensin II AT1 receptor antagonist valsartan compose LCZ696 in a 1:1 molar ratio. LCZ696 is an angiotensin receptor neprilysin inhibitor. It can reduce blood pressure and may be a novel drug for the treatment of heart failure. AHU-377 is a pro-drug, it can be converted by enzymatic cleavage of the ethyl ester into the active form LBQ657. It is reported that AHU-377(30 and 100 mg/kg, PO) can cause antihypertensive effect in a dose-dependent manner in DAHI-SS rats. But in the DOCA-salt hypertensive rats, it shows a weak reduction [2, 3].

References:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J Med Chem. 1995 May 12; 38(10):1689-700.
[2] Voors AA, Dorhout B, van der Meer P. The potential role of valsartan + AHU377 ( LCZ696 ) in the treatment of heart failure. Expert Opin Investig Drugs. 2013 Aug;22(8):1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al. Comparative efficacy of AHU-377, a potent neprilysin inhibitor, in two rat models of volume-dependent hypertension. BMC Pharmacology 2011, 11(Suppl 1):P33.

Chemical structure

Sacubitril Hemicalcium

2018 GMP-2
原料药GMP证书201811（captopril ,thalidomide etc）
GMP-of-PMDA-in-Chanyoo-平成28年08月03日　Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

OUR STRENGTH

Quality management1

Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.

Quality management2

Advanced international quality management system has laid solid foundation for sales.

Quality management3

Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect.

Quality management4

Professional Regulatory Affairs team supports the quality demands during the application and registration.

VIEW MORE

VIEW MORE

International cooperation

Domestic cooperation

Product detail pictures:

Related Product Guide:

In an effort to finest meet up with client's requirements, all of our operations are strictly performed in line with our motto "High High quality, Competitive Rate, Fast Service" for China Wholesale Calcium Rosuvastatin Suppliers - Sacubitril Hemicalcium – CPF , The product will supply to all over the world, such as: United States, Angola, Iran, We also have good cooperation relationships with many good manufacturers so that we can provide almost all of auto parts and after-sales service with high quality standard,lower price level and warmly service to meet demands of customers from different fields and different area.

Canagliflozin Renal Dosing