English

Chinese wholesale Doxycycline Monohydrate 100mg Tabs - Venetoclax 1257044-40-8 – CPF

Chinese wholesale Doxycycline Monohydrate 100mg Tabs - Venetoclax 1257044-40-8 – CPF Featured Image
  • Chinese wholesale Doxycycline Monohydrate 100mg Tabs - Venetoclax 1257044-40-8 – CPF

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

We keep improving and perfecting our products and service. At the same time, we work actively to do research and development for Canagliflozin, Agomelatine, Doxycycline Hyclate Pills, As an experienced group we also accept custom-made orders. The main intention of our firm is to build up a satisfying memory for all consumers, and set up a long-term win-win small business connection.
Chinese wholesale Doxycycline Monohydrate 100mg Tabs - Venetoclax 1257044-40-8 – CPF Detail:

维奈妥拉 Venetoclax 1257044-40-8 In-House
    VCL-6A 98549-88-3 In-House
    VCL-7A 1235865-75-4 In-House
    VCLM2 1228780-72-0 In-House
    VCLM2-2HCl 1628047-87-9 In-House
    VCLM3 1228779-96-1 In-House

Generic Name: venetoclax (ven ET oh klax)
Brand Name: Venclexta, Venclexta Starting Pack

Venetoclax is used to treat chronic lymphocytic leukemia or small lymphocytic leukemia in adults. Venetoclax is used alone or in combination with other cancer medicines to treat these conditions.

Venetoclax is used in combination with azacitidine, decitabine, or cytarabine to treat acute myeloid leukemia. This combination is for use in adults who are 75 years or older, or who cannot use standard chemotherapy due to other medical conditions.

Venetoclax is sometimes given after other treatments have failed.

Venetoclax may also be used for purposes not listed in this medication guide.

Description

Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy.

In Vitro

Venetoclax (ABT-199) potently kills FL5.12-BCL-2 cells (EC50=4 nM), Venetoclax (ABT-199) shows much weaker activity against FL5.12-BCL-XL cells (EC50=261 nM). ABT-199 also shows selectivity in cellular mammalian two-hybrid assays, where it disrupts BCL-2-BIM complexes (EC50=3 nM) but is much less effective against BCL-XL-BCL-XS (EC50=2.2 μM) or MCL-1-NOXA complexes.

After a single oral dose of 12.5 mg per kg body weight in xenografts derived from RS4;11 cells (ALL), Venetoclax (ABT-199) causes a maximal tumor growth inhibition (TGImax) of 47% (P<0.001) and tumor growth delay (TGD) of 26% (P<0.05)[1].

Treatment of established xenografted (a mouse xenograft model of the T-ALL cell line LOUCY) tumors with Venetoclax (ABT-199) 100 mg/kg for 4 days results in a significant reduction of leukemic burden.

Storage

Powder

-20°C

 3 years

4°C

 2 years
In solvent

-80°C

 6 months

-20°C

 1 month

Chemical structure

Venetoclax 1257044-40-8

2018 GMP-2
原料药GMP证书201811（captopril ,thalidomide etc）
GMP-of-PMDA-in-Chanyoo-平成28年08月03日　Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

OUR STRENGTH

Quality management1

Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.

Quality management2

Advanced international quality management system has laid solid foundation for sales.

Quality management3

Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect. 

Quality management4

Professional Regulatory Affairs team supports the quality demands during the application and registration.


VIEW MORE


VIEW MORE

International cooperation
International cooperation
Domestic cooperation
Domestic cooperation

Product detail pictures:

Chinese wholesale Doxycycline Monohydrate 100mg Tabs - Venetoclax 1257044-40-8 – CPF detail pictures

Related Product Guide:
Together with the "Client-Oriented" enterprise philosophy, a arduous good quality control technique, sophisticated producing equipment and a sturdy R&D staff, we generally offer superior quality merchandise, superb solutions and aggressive rates for Chinese wholesale Doxycycline Monohydrate 100mg Tabs - Venetoclax 1257044-40-8 – CPF , The product will supply to all over the world, such as: Buenos Aires, San Diego, Bolivia, Our items are exported worldwide. Our customers are always satisfied with our reliable quality, customer-oriented services and competitive prices. Our mission is "to continue to earn your loyalty by dedicating our efforts to the constant improvement of our merchandise and services in order to ensure the satisfaction of our end-users, customers, employees, suppliers and the worldwide communities in which we cooperate".
    • It can be said that this is a best producer we encountered in China in this industry, we feel lucky to work with so excellent manufacturer.
    5 Stars By Heather from Jersey - 2018.12.10 19:03
    The sales manager is very patient, we communicated about three days before we decided to cooperate, finally, we are very satisfied with this cooperation!
    5 Stars By Bertha from Surabaya - 2018.05.22 12:13
    Write your message here and send it to us

    Products categories