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Europe style for Doxycycline Monohydrate Pneumonia - Chlorothiazide – CPF

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Europe style for Doxycycline Monohydrate Pneumonia - Chlorothiazide – CPF Detail:

Background

Chlorothiazide is an inhibitor of carbonic anhydrase and is slightly less potent than acetazolamide. This compound has been shown to block reabsorption of sodium and chloride ions.

Description

Chlorothiazide is a diuretic and antihypertensive. (IC50=3.8 mM) Target: Others Chlorothiazide sodium (Diuril) is a diuretic used within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. It is also used as an antihypertensive. Most often taken in pill form, it is usually taken orally once or twice a day. In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). Working in a separate mechanism than furosemide, and absorbed enterically as a reconstituted suspension administered through a nasogastric tube (NG tube), the two drugs potentiate one another.

Clinical Trial

NCT Number Sponsor Condition Start Date

Phase
NCT03574857 University of Virginia Heart Failure|Heart Failure With Reduced Ejection Fraction|Heart Failure Acute|Cardiovascular Diseases June 2018

Phase 4
NCT02546583 Yale University|National Heart, Lung, and Blood Institute (NHLBI) Heart Failure August 2015

Not Applicable
NCT02606253 Vanderbilt University|Vanderbilt University Medical Center Heart Failure February 2016

Phase 4
NCT00004360 National Center for Research Resources (NCRR)|Northwestern University|Office of Rare Diseases (ORD) Diabetes Insipidus, Nephrogenic September 1995

NCT00000484 National Heart, Lung, and Blood Institute (NHLBI) Cardiovascular Diseases|Heart Diseases|Hypertension|Vascular Diseases April 1966

Phase 3

Chemical structure

Chlorothiazide

2018 GMP-2
原料药GMP证书201811（captopril ,thalidomide etc）
GMP-of-PMDA-in-Chanyoo-平成28年08月03日　Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

OUR STRENGTH

Quality management1

Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.

Quality management2

Advanced international quality management system has laid solid foundation for sales.

Quality management3

Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect. 

Quality management4

Professional Regulatory Affairs team supports the quality demands during the application and registration.


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International cooperation
International cooperation
Domestic cooperation
Domestic cooperation

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