English

Factory Cheap Hot Doxycycline Hyclate 100mg For Chlamydia - Thalidomide – CPF

Factory Cheap Hot Doxycycline Hyclate 100mg For Chlamydia - Thalidomide – CPF Featured Image
  • Factory Cheap Hot Doxycycline Hyclate 100mg For Chlamydia - Thalidomide – CPF

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

We always work as a tangible team to ensure that we can provide you with the best quality and the best price for Rosuvastatin Calcium Tablets, Losartan Hydrochlorothiazide 100 Mg 25 Mg, Sugammadex Sodium, Warmly welcome to cooperate and develop with us! we will continue to provide product with high quality and competitive price.
Factory Cheap Hot Doxycycline Hyclate 100mg For Chlamydia - Thalidomide – CPF Detail:

Background

Thalidomide was introduced as a sedative drug,immunomodulatory agent and also is investigated for treating symptoms of many cancers.Thalidomide inhibits an E3 ubiquitin ligase， which is a CRBN-DDB1-Cul4A complex.

Description

Thalidomide is initially promoted as a sedative, inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties.

In Vitro

Thalidomide is initially promoted as a sedative, has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties, and targets cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM[1]. Thalidomide (50 μg/mL) potentiates the anti-tumor activity of icotinib against the proliferation of both PC9 and A549 cells, and this effect is correlated with apoptosis and cell migration. In addition, Thalidomide and icotinib inhibits the EGFR and VEGF-R2 pathways in PC9 cells[3].

Thalidomide (100 mg/kg, p.o.) inhibits the collagen deposition, down-regulates the mRNA expression level of α-SMA and collagen I, and significantly reduces the pro-inflammatory cytokines in RILF mice. Thalidomide alleviates RILF via suppression of ROS and down-regulation of TGF-β/Smad pathway dependent on Nrf2 status[2]. Thalidomide (200 mg/kg, p.o.) combined with icotinib shows synergistic anti-tumor effects in nude mice bearing PC9 cells, suppressing tumor growth and promoting tumor death[3].

Storage

Powder

-20°C

 3 years

4°C

 2 years
In solvent

-80°C

 6 months

-20°C

 1 month

Chemical structure

Thalidomide

2018 GMP-2
原料药GMP证书201811（captopril ,thalidomide etc）
GMP-of-PMDA-in-Chanyoo-平成28年08月03日　Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

OUR STRENGTH

Quality management1

Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.

Quality management2

Advanced international quality management system has laid solid foundation for sales.

Quality management3

Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect. 

Quality management4

Professional Regulatory Affairs team supports the quality demands during the application and registration.


VIEW MORE


VIEW MORE

International cooperation
International cooperation
Domestic cooperation
Domestic cooperation

Product detail pictures:

Factory Cheap Hot Doxycycline Hyclate 100mg For Chlamydia - Thalidomide – CPF detail pictures

Related Product Guide:
We depend on sturdy technical force and continually create sophisticated technologies to meet the demand of Factory Cheap Hot Doxycycline Hyclate 100mg For Chlamydia - Thalidomide – CPF , The product will supply to all over the world, such as: Georgia, Algeria, Iran, "Good quality, Good service " is always our tenet and credo. We take every effort to control the quality, package, labels etc and our QC will check every detail during producing and before shipment. We are willing to establish long business relationship with those who seek the high quality products and good service. We have set up a wide sales network across European countries, North of America, South of America, Middle East, Africa, East Asia countries.Please contact us now, you will find our professional experience and high quality grades will contribute to your business.
    • Company director has very rich management experience and strict attitude, sales staff are warm and cheerful, technical staff are professional and responsible,so we have no worry about product,a nice manufacturer.
    5 Stars By ROGER Rivkin from Belize - 2017.11.11 11:41
    Wide range, good quality, reasonable prices and good service, advanced equipment, excellent talents and continuously strengthened technology forces，a nice business partner.
    5 Stars By Victor Yanushkevich from Ecuador - 2017.01.28 18:53
    Write your message here and send it to us

    Products categories