Sacubitril Manufacturer

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  • Hot sale Olmesartan Medoxomil And Hydrochlorothiazide Tablets - Venetoclax 1257044-40-8  – CPF

    Hot sale Olmesartan Medoxomil And Hydrochlorothiazide Tablets - Venetoclax 1257044-40-8 – CPF

    维奈妥拉 Venetoclax 1257044-40-8 In-House     VCL-6A 98549-88-3 In-House     VCL-7A 1235865-75-4 In-House     VCLM2 1228780-72-0 In-House     VCLM2-2HCl 1628047-87-9 In-House     VCLM3 1228779-96-1 In-House Generic Name: venetoclax (ven ET oh klax) Brand Name: Venclexta, Venclexta Starting Pack Venetoclax is used to treat chronic lymphocytic leukemia or small lymphocytic leukemia in adults. Venetoclax is used alone or in combination with other cancer medicines to trea...
  • Factory source Ledipasvir Pvp - Daclatasvir Dihydrochloride  – CPF

    Factory source Ledipasvir Pvp - Daclatasvir Dihydrochloride – CPF

    Description Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir dihydrochloride is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 µM and 3.27 µM, respectively. IC50 & Target EC50: 50 pM (HCV replicon genotype 1a), 9 pM (HCV replicon genotype 1b), 71 pM (HCV replicon genotype 2a), 146 pM (HCV replicon ...
  • OEM/ODM Supplier Pitavastatin Manufacturer - Niraparib 1038915-60-4  – CPF

    OEM/ODM Supplier Pitavastatin Manufacturer - Niraparib 1038915-60-4 – CPF

    Description Niraparib (MK-4827) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity.   In Vitro Niraparib (MK-4827) inhibits PARP activity with EC50=4 nM and EC90=45 nM in a whole cell assay. MK-4827 inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10-100 nM range. MK-4827 displays exce...
  • China Wholesale Brilinta Ticagrelor Manufacturers - Sacubitril Hemicalcium  – CPF

    China Wholesale Brilinta Ticagrelor Manufacturers - Sacubitril Hemicalcium – CPF

        沙库比曲半钙盐 Sacubitril Hemicalcium 1369773-39-6 In-House     沙库比曲钠盐 149690-05-1 In-House     LCZ-4 1426129-50-1 In-House     LCZ-7 1012341-48-8 In-House     LCZ-8 1012341-50-2 In-House     LCZ-9 149690-12-0 In-House   Background AHU-377 hemicalcium salt is a hemicalcium salt form of AHU-377. It is an inhibitor of neprilysin with IC50 value of 5 nM [1]. AHU-377 and the angiotensin II AT1 receptor antagonist valsartan compose LCZ696 in a 1:1 molar ra...
  • 2020 wholesale price Canagliflozin Ppt - Pregabalin  – CPF

    2020 wholesale price Canagliflozin Ppt - Pregabalin – CPF

    Pregabalin is not a GABAA or GABAB receptor agonist. Pregabalin is a gabapentinoid and acts by inhibiting certain calcium channels. Specifically it is a ligand of the auxiliary α2δ subunit site of certain voltage-dependent calcium channels (VDCCs), and thereby acts as an inhibitor of α2δ subunit-containing VDCCs. There are two drug-binding α2δ subunits, α2δ-1 and α2δ-2, and pregabalin shows similar affinity for (and hence lack of selectivity between) these two sites. Pregabalin is selective i...
  • PriceList for Atenolol Hydrochlorothiazide - LOXO-101 1223403-58-4  – CPF

    PriceList for Atenolol Hydrochlorothiazide - LOXO-101 1223403-58-4 – CPF

    Background IC50: low nanomolar range for inhibition of all TRK family members LOXO-101 is a tropomyosin receptor kinases (TRK) inhibitor. The TRK family of neurotrophin receptors and their neurotrophin ligands regulate neuron growth, differentiation and survival. In vitro: In previous study, LOXO-101 was evaluated for off-target kinase enzyme inhibition against a panel of non-TRK kinases at a concentration of 1,000 nM and ATP concentrations around the Km. Results showed that LOXO-101 had grea...
  • Hot sale Olmesartan Medoxomil And Hydrochlorothiazide Tablets - Ribociclib 1374639-75-4  – CPF

    Hot sale Olmesartan Medoxomil And Hydrochlorothiazide Tablets - Ribociclib 1374639-75-4 – CPF

    Description Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.   In Vitro Treating a panel of 17 neuroblastoma cell lines with Ribociclib (LEE011) across a four-log dose range (10 to 10,000 nM). Treatment with Ribociclib significantly inhibits substrate adherent growth relative to the control in 12 of the 17 neuroblastoma cell lines examined (mean IC50=306±68 nM, con...
  • China Wholesale Ticagrelor 90 Mg Tablet Suppliers - Agomelatine  – CPF

    China Wholesale Ticagrelor 90 Mg Tablet Suppliers - Agomelatine – CPF

    Background Agomelatine is an agonist of melatonin receptors and an antagonist of the serotonin 5-HT2C receptor with Ki values of 0.062nM and 0.268nM and IC50 value of 0.27μM, respectively for MT1, MT2 and 5-HT2C [1]. Agomelatine is a unique antidepressant and is developed for treatment of major depressive disorder (MDD). Agomelatine is selective against 5-HT2C. It shows low affinities to cloned human 5-HT2A and 5-HT1A. For melatonin receptors, agomelatine shows similar affinities to cloned hu...
  • Hot Sale for Amiloride And Hydrochlorothiazide - Chlorothiazide  – CPF

    Hot Sale for Amiloride And Hydrochlorothiazide - Chlorothiazide – CPF

    Background Chlorothiazide is an inhibitor of carbonic anhydrase and is slightly less potent than acetazolamide. This compound has been shown to block reabsorption of sodium and chloride ions. Description Chlorothiazide is a diuretic and antihypertensive. (IC50=3.8 mM) Target: Others Chlorothiazide sodium (Diuril) is a diuretic used within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. It is also used as an antihypertensive. Most often...
  • Reasonable price Rosuvastatin Calcium 40 Mg Tablet - Massive Selection for Doxycycline Hyclate 100 Tablet - Captopril  – CPF  – CPF

    Reasonable price Rosuvastatin Calcium 40 Mg Tablet - Massive Selection for Doxycycline Hyclate 100 Tablet - Captopril – CPF – CPF

    Description Captopril (SQ-14534) is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE). In Vitro Captopril (SQ-14534) has been shown to have similar morbidity and mortality benefits to those of diuretics and beta-blockers in hypertensive patients. Captopril (SQ-14534) has been shown to delay the progression of diabetic nephropathy, and enalapril and lisinopril prevent the development of nephropathy in normoalbuminuric patients with diabetes[1]. An equimolar ratio of the c...
  • Best-Selling Boceprevir And Telaprevir - Tofacitnib Citrate  – CPF

    Best-Selling Boceprevir And Telaprevir - Tofacitnib Citrate – CPF

    Background Tofacitinib citrate, also known as CP-690550 citrate, is a potent inhibitor of janus kinase 3 (JAK3), a hematopoetic cell-restricted tyrosine kinase involved in signal transduction regulating lymphocyte survival, proliferation, differentiation, and apoptosis.  The inhibition is JAK3 specific with a selectivity 1000-fold more than other non-JAK family kinases. Besides inhibiting JAKS (IC50 = 1 nM), tofacitinib citrate also inhibits janus kinase 2 (JAK2) and janus kinase 1 (JAK1) wit...
  • Factory Cheap Losartan Hydrochlorothiazide 100 Mg 25 Mg - Hydrochlorothiazide  – CPF

    Factory Cheap Losartan Hydrochlorothiazide 100 Mg 25 Mg - Hydrochlorothiazide – CPF

    Description Hydrochlorothiazide (HCTZ), an orally active diuretic drug of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect. Background Hydrochlorothiazide is a diuretic drug of the thiazide class. In Vitro Hydrochlorothiazide belongs to thiazide class of di...