China Factory Cheap Losartan Hydrochlorothiazide 100 Mg 25 Mg - Hydrochlorothiazide – CPF manufacturers and suppliers

Factory Cheap Losartan Hydrochlorothiazide 100 Mg 25 Mg - Hydrochlorothiazide – CPF

Short Description:

Product Detail

Product Tags

Feedback (2)

Our workforce through professional training. Skilled professional knowledge, solid sense of service, to fulfill the services demands of consumers for Effects Of Thalidomide, Pregabalin Gabapentin, Doxycycline Mono Hyclate 100mg, We are also constantly looking to establish relationship with new suppliers to provide innovative and smart solution to our valued customers.

Factory Cheap Losartan Hydrochlorothiazide 100 Mg 25 Mg - Hydrochlorothiazide – CPF Detail:

Description

Hydrochlorothiazide (HCTZ), an orally active diuretic drug of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect.

Background

Hydrochlorothiazide is a diuretic drug of the thiazide class.

In Vitro

Hydrochlorothiazide belongs to thiazide class of diuretics. It reduces blood volume by acting on the kidneys to reduce sodium (Na) reabsorption in the distal convoluted tubule. The major site of action in the nephron appears on an electroneutral Na+-Cl co-transporter by competing for the chloride site on the transporter. By impairing Na transport in the distal convoluted tubule, hydrochlorothiazide induces a natriuresis and concomitant water loss. Thiazides increase the reabsorption of calcium in this segment in a manner unrelated to sodium transport. Additionally, by other mechanisms, Hydrochlorothiazide is believed to lower peripheral vascular resistance.

Hydrochlorothiazide (HCTZ; orally bygavage; 12.5 mg/kg/d; 8 weeks) has improved cardiac function, reduced cardiac interstitial fibrosis and collagen volume fraction, decreased expression of AT1, TGF-β and Smad2 in the cardiac tissues in adult male Sprague Dawley rats. In addition, hydrochlorothiazide reduces plasma angiotensin II and aldosterone levels. Furthermore, hydrochlorothiazide inhibits angiotensin II-induced TGF-β1 and Smad2 protein expression in the neonatal rat ventricular fibroblasts.

Chemical structure

2018 GMP-2
原料药GMP证书201811（captopril ,thalidomide etc）
GMP-of-PMDA-in-Chanyoo-平成28年08月03日　Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

OUR STRENGTH

Quality management1

Proposal 18 Quality Consistency Evaluation projects which have approved 4, and 6 projects are under approving.

Quality management2

Advanced international quality management system has laid solid foundation for sales.

Quality management3

Quality supervision runs through the whole life cycle of the product to ensure the quality and therapeutic effect.

Quality management4

Professional Regulatory Affairs team supports the quality demands during the application and registration.

VIEW MORE

VIEW MORE

International cooperation

Domestic cooperation

Product detail pictures:

Related Product Guide:

We consistently execute our spirit of ''Innovation bringing progress, Highly-quality ensuring subsistence, Administration advertising and marketing gain, Credit history attracting buyers for Factory Cheap Losartan Hydrochlorothiazide 100 Mg 25 Mg - Hydrochlorothiazide – CPF , The product will supply to all over the world, such as: Sri Lanka, Slovakia, Lahore, We aim to become the modern enterprise with the commercial ideal of "Sincerity and confidence" and with the aim of "Offering customers the most sincere services and best quality products". We sincerely ask for your unchanged support and appreciate your kind advice and guidance.

China Wholesale Rosuvastatin Calcium 5 Mg Tab Tablet Manufacturers

China Wholesale Tab Ticagrelor Manufacturers

China Wholesale Ticagrelor Tab Factory

Doxycycline And Doxycycline Hyclate

Sacubitril Manufacturer

The supplier abide the theory of "quality the basic, trust the first and management the advanced" so that they can ensure a reliable product quality and stable customers.